Miura Shiori is a friendless girl with an expressionless face. She wants to become proctologist and cure people's hemorrhoids. She found out that a boy from her school, Yakushiji Teruki has hemorrhoids so under the pretext of helping him she used him as guinea pig for her research. Since she used to have hemorrhoids herself she called the both of them "jiyuujin," a play on words "hemo," "friends" and "freedom."

At first she seen Yakushiji only as a friend and research subject, but through his actions and words unaware to herself she developed feelings for him.

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