Not too much is known about Deadpool's childhood. At some point of his life, Wade Wilson joined Project X.

Little is known of Wilson's subsequent mercenary activities. At one point he was active in Tangier, Morocco where he romanced a woman named Francie. When this relationship soured, he traveled throughout Asia, and was hired in Japan by a crime lord, the Boss, to infiltrate a sumo-wrestling ring owned by a rival criminal, the Oyakata. Wilson spent three years as a wrestler under the Oyakata's tutelage and became romantically involved with his Mentor’s daughter, Sazae. When the Boss finally ordered the Oyakata's murder, Wilson refused to complete his assignment, allegedly the first time he had ever done so, and relocated to the United States.

In America, Wade met and fell in love with mutant teenage prostitute Vanessa Carlysle, with whom he shared dreams of a better life. Wilson was subsequently hired by Middle Eastern interests to assassinate a blind British Government operative named Althea, also known as Blind Al. Upon arrival at the Zaire base where she was stationed, he killed everyone except for Al who had fled.

Wilson’s employers sought vengeance for his failure by targeting Vanessa, who was rescued by Zoe Culloden, an employee of the inter-dimensional firm Landau, Luckman, Lake, and LeQuare. Culloden was keeping Wilson under surveillance, believing he was destined to play a vital part in a potential threat to the World. Learning that he had contracted cancer, Wilson broke up with his girlfriend Vanessa rather than force her to remain with a terminally ill man. He even gave up his chemo treatments, not wishing to prolong things.

(Source: Marvel Database)